Why Is a Partial Agonist of Theoretical Interest Inschizophrenia?
نویسندگان
چکیده
generated interest in their therapeutic potential in schizophrenia. This has been driven, in part, by the recent approval of the dopamine (D2) receptor partial agonist aripiprazole in the USA and Europe. In comparison with conventional and atypical antipsychotics that mediate their therapeutic effects by D2 receptor blockade, aripiprazole has a unique mechanism of action. However, the concept of partial agonists for the treatment of schizophrenia is not entirely novel, since aripiprazole is one of several members of this class of drug. This editorial reviews the neurochemistry of dopamine in schizophrenia and discusses the theoretical importance of partial agonism as a mechanism for the treatment of this illness. We also summarise the historical information on previous trials of partial agonists in schizophrenia and evaluate other dopamine receptor partial agonists that are currently under development.
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